Question 10 Programmed cell death pathway is associated with p53. No answer text provided. True No answer text provided. False
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11) Identify whether following statements are True (T) or False (F) regarding programmed cell death. (1pt each) ____Programmed cell death does not contribute to normal animal development ____Apoptosis can be stimulated by both external and internal signals ____The only form of programmed cell death is apoptosis ____DNA fragmentation is used as a marker for apoptosis ____Release of cytochrome c will always induce apoptotic cell death.
Md.Daniyal A.
Which one of the following statements about apoptosis is false? a. It is an important anti-tumor suppression mechanism. b. It may be triggered by extracellular death signals that act via the extrinsic pathway. c. It may be triggered by internal stimuli such as DNA damage. d. It is regulated cell death. e. All of the above. 2. p53 gene, located on chromosome a. 17p13 b. 17p14 c. 18p13 d. 18p14 e. None of the above. 3. What is the role of PTEN (phosphate and tensin homolog) on chromosome 10? a. Dephosphorylation of PIP2 to form PIP3. b. Dephosphorylation of the membrane lipid PIP3 to form PIP1. c. To cause Cowden syndrome.. d. To remove inhibitory signals and hence induce kinase activity. e. None of the above 4. What is the TATA box a. a promotor region b. a operator region c. transcription start site d. None of the above e. All of the above 5. Which of the following is not a structural motif found in a DNA-binding domain? a. coiled-coiled b. zinc-finger c. helix-loop-helix d. Beta Barrell e. All are structural motiffs 6. Which one of the statements below about the intrinsic pathway of apoptosis is false? a. The intrinsic pathway is mediated by the mitochondria. b. The intrinsic pathway of apoptosis depends on external death factors TNF and Fas. c. Internal stimuli, such as DNA damage and oxidative stress, induce the intrinsic pathway of apoptosis. d. The intermembrane space between the 2 mitochondrial membranes acts as a supply cabinet for apoptotic mediators of the intrinsic pathway.
Sri K.
Which of the following statements is false? a. p53 acts as a brake on cell growth but stimulates apoptotic pathways. b. Apoptosis occurs only after a death signal is received by one cell from another cell. c. Caspases proteolyze cellular proteins. d. The death signal starts a pathway that culminates in the activation of a class of proteolytic enzymes called caspases.
Ronald P.
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