Question 12 0.5 pts Which of the following is NOT true about the glycosylation of proteins. a transmembrane protein is often glycosylated secreted proteins are often glycoproteins O-linked glycosylation occurs in the Golgi lumen cytosolic proteins are often glycosylated N-linked glycosylation occurs in the RER lumen Question 13 0.5 pts A GPCR (G-protein coupled receptor) is situated in the plasma membrane with its amino-terminal on the extracellular side of the membrane, and its carboxy-terminal on the cytosolic side of the membrane. The GPCR spans the membrane seven times. Which of the following is correct regarding the sequences of this protein that led to this orientation in the membrane? Legend: Stop transfer sequence (anchor sequence) = Stop Start transfer sequence = Start It had a signal peptide located in the middle of the protein (removed) It had an N-terminal signal peptide (retained) it had the following sequences directing its membrane topology: N-terminal signal peptide (removed)-Stop-Start-Stop-Start-Stop-Start-Stop Question 14 0.5 pts Which of the following statements is true regarding the positioning of a transmembrane protein in the plasma membrane? What is luminal ends up outside the cell (extracellular) What is cytosolic ends up outside the cell (extracellular) What is cytosolic may flip to the luminal side of the membrane, so end up outside the cell (extracellular)
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3) Which statement is NOT true regarding signal sequences? A) Proteins without signal sequences remain in the cytoplasm B) They are often cleaved from the mature protein C) Are only found on nuclear proteins D) Are specific amino acid sequences that designate where a protein will be transported 4) Proteins that will be localized to the plasma membrane are first translated here. A) Golgi B) Endosomes C) Endoplasmic Reticulum D) Lysosomes 5) Which statement is true regarding the signal recognition particle? A) It pauses translation as a ribosome becomes associated with the ER. B) It pauses translation as a ribosome becomes associated with the mitochondria. C) It degrades the signal recognition particle receptor D) Remains covalently bound to the ER signal sequence. 6) This membrane protein will recognize and bind to a vesicle ensuring the vesicle is transported to the correct destination in a cell. A) ran-GTP B) Translocation channel proteins C) v-Snare protein D) t-Snare protein 7) Constitutive secretion: A) is activated by an extracellular signal. B) occurs continuously in certain cells. C) can be paused. D) is characterized by regulated membrane fusion. 8) Which statement is not true regarding lysosomes? A) Lysosomes contain proteases B) The internal pH of the lysosome is the same as the cytoplasm C) Proteins, nucleotides, and sugars are hydrolyzed here. D) Protons are continuously pumped in. 9) Hydrolases in the lysosomes will function: A) only at a pH above the cytoplasm. B) only at a pH that is the same as the cytoplasm. C) only at a pH below the cytoplasm. D) at a very wide pH range. 10) The surrounding of a damaged mitochondria with a membrane and its subsequent digestion by fusing with a lysosome is: A) Autophagy. B) Endocytosis. C) Phagocytosis. D) Regulated Secretion. 11) A small hydrophobic signaling molecule such as estrogen will bind to this class of receptor in the cell receiving the signal. A) A transmembrane receptor B) An intracellular receptor C) A G-protein Coupled Receptor D) An Ion Coupled Channel Receptor
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QUESTION 37 Which is true of the constitutive exocytosis pathway? It packages proteins in secretory vesicles that accumulate near the plasma membrane. It operates continually in all eukaryotic cells. It replaces the regulated exocytosis pathway in cells specialized for secretion. It packages proteins that form aggregates in the conditions present in the trans Golgi. QUESTION 38 Which of the following statements is true regarding cell signaling? The three stages of cell signaling include signal reception, signal transduction, and cellular response. A basic property of signaling pathways is the amplification of the response to a given stimulus. Signal amplification can be obtained during cell signaling by kinase cascades. All of the above are true. QUESTION 39 Which of the following statements about vesicular transport is FALSE? Rab proteins are involved in the selection of the vesicle cargo. The interactions of the v-SNAREs and t-SNAREs pull the vesicle membrane and the target organelle together so that their lipids can intermix. NSF and SNAP disassemble the SNARE complex so the SNAREs can be recycled.
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