QUESTION 13 _____ lymphoma is a specialized form of lymphoma that features the presence of an abnormal cell called a Reed-Sternberg cell.
Added by Gina C.
Close
Step 1
Step 1: The question asks to fill in the blank with the name of a lymphoma that is characterized by the presence of Reed-Sternberg cells. Show more…
Show all steps
Your feedback will help us improve your experience
Adi S and 78 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
A 23-year-old man presented with malaise, night sweats, loss of weight, and intermittent fever dating from a flu-like illness 3 months previously. On examination, he had bilateral, cervical, and axillary lymphadenopathy; the glands were 2-5cm in diameter, firm, rubbery, discrete, and fairly mobile. His liver and spleen were not enlarged. Investigation showed that his hemoglobin was low (113g/l) and the white-cell count was normal (4.2 x 10^9/l), but his erythrocyte sedimentation rate (ESR) was 78mm/h; the blood film did not show any abnormal cells. No enlargement of the hilar glands was seen on chest X-ray, unlike in Figure where enlarged hilar lymph nodes are obvious. A cervical lymph node was removed for histology. The gross architecture of the node was destroyed; the tissue consisted of histiocytes, eosinophils, lymphocytes, and giant cells known as Reed-Sternberg cells. These large binucleate cells are characteristic of Hodgkin's disease. A bone marrow examination was normal and computed tomography showed no involvement of other lymph nodes. This patient had stage 2 Hodgkin's disease because, although only lymphoid tissue above the diaphragm was involved, his ESR was above 40mm/h. In view of his symptoms, the suffix 'B' was added to the stage which suggests a poorer prognosis associated with systemic symptoms, so he was given cytotoxic therapy.
Adi S.
CASE STUDY A Hodgkin's Disease, JR, age 32 years, noticed a lump on the side of his neck a few months ago. The lump is relatively large, painless, and not tender to the touch. A few days ago, he experienced some difficulty swallowing as if there was something putting pressure on his esophagus. He has also noticed unexplained weight loss, fever, night sweats, and general fatigue over the last few weeks. A visit to his physician produced lab results showing a marked decrease in the lymphocyte count as well as the presence of a giant cell in the tissue of a biopsied lymph node; subsequently confirmed as a Reed-Sternberg cell. The lab results confirmed Hodgkin's lymphoma.
Sri K.
John has been living in Southern California and owns a landscaping and maintenance business. He maintained several business and home lawns and landscaping, including watering, mowing, adding fertilizer, and weed killer. This week, John started feeling very fatigued, having terrible night sweats and feverish, and losing weight. He went to the doctor, and the exam found that his inguinal lymph nodes are swollen but not painful. He was sent to an oncologist, and further testing determined he has non-Hodgkin lymphoma. He started treatment with chemo and the drug Rituxan. 1) How are the clinical presentations different between Hodgkin and Non-Hodgkin Lymphoma? 2) How do the two differ in the type of cells involved? 3) What is Rituxan, and how does it affect the cancer cells? 4) What region of the lymph node did John's lymphoma occur? 5) What is the difference in treatment strategies between slow-growing vs fast-growing lymphomas?
Madhur L.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD