QUESTION 14 The following pedigree shows the inheritance of a disease due to a completely penetrant sex-linked mutation. Indicate which of the following statements are true. A. The probability the son indicated by the question mark will have the disease is 1/2. B. The mutant allele is on the Y chromosome. C. The mutant allele is recessive and on an autosome. D. The mutant allele is dominant and on an autosome. E. The mutant allele is dominant and on the X chromosome. F. The probability the son indicated by the question mark will have the disease is 1/4. G. The probability the son indicated by the question mark will have the disease is 1/3. H. The mutant allele is recessive and on the X chromosome.
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Please answer the following questions about an X-linked mutant trait (W) based on the pedigree shown above right. And, explain why: (1) What are the genotypes of individual 1, 2 in generation I and 5, 6 in generation II? (2) What is the probability for individual 4 in generation II to be heterozygous for the mutant trait? (3) What is the probability for individual T in generation III to carry the mutant allele? To have the mutant phenotype? (4) What is the probability for individual 6 in generation II to have the mutant phenotype? (5) What is the probability for 2 out of 6 individuals in generation I to not have the mutant phenotype?
Adi S.
Pedigree 1: What is the most likely mode of inheritance of this disease given its pattern on the pedigree? Autosomal Dominant Autosomal Recessive X-Linked Dominant X-Linked Recessive QUESTION 2 Pedigree 1: What is the genotype of individual #1? AA Aa aa XAXA XAXa XaXa XAY XaY QUESTION 3 Pedigree 1: What is the probability that individual #4 is a carrier of this disease (heterozygous) if his mother is homozygous dominant and his father is heterozygous? 0% 25% 50% 75% 100%
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