Question

QUESTION 15 Which of the following is not true regarding the second tetrahedral intermediate in amide hydrolysis by chymotrypsin? A. This intermediate is stabilized by the oxyanion hole. B. Hydrogen bonding from the imidazole of histidine assists the amino group in leaving upon collapse of the tetrahedral intermediate. C. This intermediate is on the pathway of an ester being converted to a carboxylic acid. D. This intermediate involves the active site serine. QUESTION 16 The accepted mechanisms of both chymotrypsin and lysozyme have which of the following charcteristics in common? A. Both enzymes have an oxyanion hole. B. Both mechanisms involve the formation of a covalent intermediate between the enzyme and substrate. C. Both mechanisms involve activation of water molecule in the first step. D. Both mechanisms involve fully charged intermediates. E. Both mechanisms involve tetrahedral intermediates.

          QUESTION 15
Which of the following is not true regarding the second tetrahedral intermediate in amide hydrolysis by chymotrypsin?
A. This intermediate is stabilized by the oxyanion hole.
B. Hydrogen bonding from the imidazole of histidine assists the amino group in leaving upon collapse of the tetrahedral
intermediate.
C. This intermediate is on the pathway of an ester being converted to a carboxylic acid.
D. This intermediate involves the active site serine.
QUESTION 16
The accepted mechanisms of both chymotrypsin and lysozyme have which of the following charcteristics in common?
A. Both enzymes have an oxyanion hole.
B. Both mechanisms involve the formation of a covalent intermediate between the enzyme and substrate.
C. Both mechanisms involve activation of water molecule in the first step.
D. Both mechanisms involve fully charged intermediates.
E. Both mechanisms involve tetrahedral intermediates.

QUESTION 15
Which of the following is not true regarding the second tetrahedral intermediate in amide hydrolysis by chymotrypsin?
A. This intermediate is stabilized by the oxyanion hole.
B. Hydrogen bonding from the imidazole of histidine assists the amino group in leaving upon collapse of the tetrahedral
intermediate.
C. This intermediate is on the pathway of an ester being converted to a carboxylic acid.
D. This intermediate involves the active site serine.
QUESTION 16
The accepted mechanisms of both chymotrypsin and lysozyme have which of the following charcteristics in common?
A. Both enzymes have an oxyanion hole.
B. Both mechanisms involve the formation of a covalent intermediate between the enzyme and substrate.
C. Both mechanisms involve activation of water molecule in the first step.
D. Both mechanisms involve fully charged intermediates.
E. Both mechanisms involve tetrahedral intermediates.

Added by Andrew J.

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