Question 24 (3 points) Ligands that are hydrophilic typically act on receptors in the cytosol, while ligands that are hydrophobic usually only binds to transmembrane receptor proteins. True False
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Step 1: The statement says that hydrophilic ligands act on receptors in the cytosol, and hydrophobic ligands bind to transmembrane receptor proteins. Show more…
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Ronald P.
Which of the following statements is FALSE: A) There are cell surface receptors (e.g., GPCRs, ion-channel linked receptors, and RTKs) and intracellular receptors (cytosolic or nuclear localized). B) Ligands which bind to GPCRs are hydrophilic whereas ligands which bind to hormone receptors are hydrophobic. C) Hydrophilic ligands cannot diffuse through the plasma membrane whereas hydrophobic ligands can. D) The ligand binding domain of a hormone receptor does not undergo a large conformational change when bound to a ligand.
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What property prevents the ligands of cell-surface receptors from entering the cell? a. The molecules bind to the extracellular domain. b. The molecules are hydrophilic and cannot penetrate the hydrophobic interior of the plasma membrane. c. The molecules are attached to transport proteins that deliver them through the bloodstream to target cells. d. The ligands are able to penetrate the membrane and directly influence gene expression upon receptor binding.
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