A mutation in the mRNA for the protein chymotrypsin results in a codon sequence of 5'-UAU-3' (instead of 3'-UAC-5'). Which of the following aberrations in protein synthesis might this mutation cause? Middle Letter First Letter U Reading frame 5' 3' UUU Phenylalanine UUC Phenylalanine UUA Leucine UUG Leucine C Reading frame 5' 3' UCU Serine UCC Serine UCA Serine UCG Serine A Reading frame 5' 3' UAU Tyrosine UAC Tyrosine UAA (Stop) UAG (Stop) G Reading frame 5' 3' UGU Cysteine UGC Cysteine UGA (Stop) UGG Tryptophan Last Letter U C A G C CUU Leucine CUC Leucine CUA Leucine CUG Leucine CCU Proline CCC Proline CCA Proline CCG Proline CAU Histidine CAC Histidine CAA Glutamine CAG Glutamine CGU Arginine CGC Arginine CGA Arginine CGG Arginine U C A G A AUU Isoleucine AUC Isoleucine AUA Isoleucine AUG Methionine (Start) ACU Threonine ACC Threonine ACA Threonine ACG Threonine AAU Asparagine AAC Asparagine AAA Lysine AAG Lysine AGU Serine AGC Serine AGA Arginine AGG Arginine U C A G G GUU Valine GUC Valine GUA Valine GUG Valine GCU Alanine GCC Alanine GCA Alanine GCG Alanine GAU Aspartate GAC Aspartate GAA Glutamate GAG Glutamate GGU Glycine GGC Glycine GGA Glycine GGG Glycine U C A G It would result in a shortened protein chain It would not have any change since there the genetic code degenerate It would result in an amino acid substitution It would result in a read through mutation
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17) The following DNA sequence encodes part of the C-terminus of a prokaryotic protein. Use the codon table provided as needed to answer the following questions (assume upper strand is sense): 5ā²-CAA-GCT-GTA-AGA-GTG-TGA-CTG-GTG-3ā² 3ā²-GTT-CGA-CAT-TCT-CAC-ACT-GAC-CAC-5ā² (A) Write the mRNA sequence that results from the transcription of this sequence. (1pt) (B) Write the translated amino acid sequence that will appear in the C-terminus of the protein (1pt) (C) How will the sequence change if a suppressor alanine tRNA recognizes the first stop codon?(1pt) D) If a mutation occurs that results in the deletion of G from the 3ā-end of codon #5 how will this change the the C-terminal sequence of the protein? (1pt) E) Explain how the degeneracy of the code limited the impact of deletion mutation introduced in question D? (1pt)
Madhur L.
A. What amino acid sequence would result from translation of the following mRNA molecule? mRNA: 5' - AUG CGG UUA UUG CUA CUG UCA UAG - 3' Polypeptide: (Use the 3 letter codes with spaces in between each amino acid) B. There is a mutation in the DNA so that the mRNA sequence also altered as show below (mutation in bold): mutant mRNA: 5' - AUG CGG UUU AUU GCU ACU GUC AUA G - 3' What two terms could be used to describe this mutation? (hint: one describes how the DNA is changed, the other describes the effect that change has)
Rachel G.
Below are several DNA sequences that are mutated compared with the wild-type sequence: $3^{\prime}-\mathrm{T} \mathrm{A} \mathrm{C} \mathrm{T} \mathrm{G} \mathrm{A}$ C T G A C G A T C-5'. Envision that each is a section of a DNA molecule that has separated in preparation for transcription, so you are only seeing the template strand. Construct the complementary DNA sequences (indicating 5' and 3' ends) for each mutated DNA sequence, then transcribe (indicating 5' and 3' ends) the template strands, and translate the mRNA molecules using the genetic code, recording the resulting amino acid sequence (indicating the $\mathrm{N}$ and C termini). What type of mutation is each? Mutated DNA Template Strand #1: 3'-T A C T G T C T G A C G A T C-5' Complementary DNA sequence:mRNA sequence transcribed from template:Amino acid sequence of peptide:Type of mutation: Mutated DNA Template Strand #2: 3'-T A C G G A C T G A C G A T C-5' Complementary DNA sequence: mRNA sequence transcribed from template: Amino acid sequence of peptide: Type of mutation: Mutated DNA Template Strand #3: 3'-T A C T G A C T G A C T A T C-5' Complementary DNA sequence: mRNA sequence transcribed from template: Amino acid sequence of peptide: Type of mutation: Mutated DNA Template Strand #4: 3'-T A C G A C T G A C T A T C-5' Complementary DNA sequence: mRNA sequence transcribed from template: Amino acid sequence of peptide: Type of mutation:
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