Question

Regulatory particle Core particle Regulatory particle Rpn10 ? rings ? ring Polyubiquitin chain Ubiquitin released Target protein threaded into proteasome Short peptides Protein substrate Ubiquitin Considering all the effort it takes to make proteins, what benefit would a system like the 26S proteasome serve in eukaryotic cells? Occasionally it is necessary to rapidly remove proteins such as during the cell cycle when they are no longer needed and could lead to cancer. Since mRNA has a short half-life, it makes sense that proteins should be degraded even more quickly Proteins should be checked for errors just like DNA and RNA and a system like the proteasome can degrade improperly made proteins. Proteins made in the cytoplasm need to be turned over more often than those in the nucleus so this system allows for their rapid degradation.

          Regulatory particle
Core particle
Regulatory particle
Rpn10
? rings
? ring
Polyubiquitin chain
Ubiquitin released
Target protein threaded into proteasome
Short peptides
Protein substrate
Ubiquitin
Considering all the effort it takes to make proteins, what benefit would a system like the 26S proteasome serve in eukaryotic cells?
Occasionally it is necessary to rapidly remove proteins such as during the cell cycle when they are no longer needed and could lead to cancer.
Since mRNA has a short half-life, it makes sense that proteins should be degraded even more quickly
Proteins should be checked for errors just like DNA and RNA and a system like the proteasome can degrade improperly made proteins.
Proteins made in the cytoplasm need to be turned over more often than those in the nucleus so this system allows for their rapid degradation.

Regulatory particle
Core particle
Regulatory particle
Rpn10
? rings
? ring
Polyubiquitin chain
Ubiquitin released
Target protein threaded into proteasome
Short peptides
Protein substrate
Ubiquitin
Considering all the effort it takes to make proteins, what benefit would a system like the 26S proteasome serve in eukaryotic cells?
Occasionally it is necessary to rapidly remove proteins such as during the cell cycle when they are no longer needed and could lead to cancer.
Since mRNA has a short half-life, it makes sense that proteins should be degraded even more quickly
Proteins should be checked for errors just like DNA and RNA and a system like the proteasome can degrade improperly made proteins.
Proteins made in the cytoplasm need to be turned over more often than those in the nucleus so this system allows for their rapid degradation.

Added by Alicia M.

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