Question 4B A drug given as a 100-mg single dose, results in...

Question 4B A drug given as a 100-mg single dose, results in a peak plasma concentration of 20 ?g/mL. The apparent volume of distribution is (assume a rapid distribution and negligible elimination prior to measuring the peak plasma level): A. 50.0 L B. 1.0 L C. 0.5 L D. 5.0 L

The equation that best fits the plasma analysis level curve after an i.v. in 2000 mg bolus (assuming one compartment kinetics) is C = 143e^(-0.87t). Calculate: A) The apparent volume of distribution B) The mean elimination time C) Drug concentration in plasma after 6 hours D) The amount of drug that will remain in the body after 6 hours E) When should the next dose be taken if the drug is ineffective when the plasma level falls below 50 micrograms/mL? F) The therapeutic index of the drug if the therapeutic range is 50 to 500 micrograms/mL G) How many doses must be administered to reach an instantaneous plasma concentration of 500 micrograms/mL H) For how long will the plasma level fall in the therapeutic window if the previous dose is given as i.v. bolus?

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Question 4B A drug given as a 100-mg single dose, results in a peak plasma concentration of 20 ?g/mL. The apparent volume of distribution is (assume a rapid distribution and negligible elimination prior to measuring the peak plasma level): A. 50.0 L B. 1.0 L C. 0.5 L D. 5.0 L

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