Question 9 Zero-order drug elimination kinetics are most...

Question 9 Zero-order drug elimination kinetics are most commonly observed when... The half-life of the drug is exceeded. The elimination mechanisms for the drug are saturated. The volume of distribution of the drug is increased. The metabolism pathways for the drug are induced. When the drug is being absorbed. Question 10 The time is 4:00 PM. Your patient has a plasma drug concentration of 500 mcg/mL. The elimination half-life for this drug is 6 hours. The expected minimal effective plasma concentration for this drug is 125 mcg/mL. You should give this patient another dose of drug at or before what time? 10 PM tonight 10 AM tomorrow 4 AM tomorrow 4 PM tomorrow 5 PM today

Transcript

00:01 Hello student here the question is given and the question is regarding zero order drug elimination kinetics.

00:14 So what are these zero order drug elimination? so if we discuss this, so there are two types of elimination kinetics occur in our body.

00:41 So these are the zero order or it could also be a first order.

00:50 So in case of the first order, the elimination is done by the certain protein.

00:56 So in this case, elimination done by certain protein and that protein already present in body, already present in body and as the amount of drug increase as amount of drugs increase so due to the increase of this amount of drug the more protein binding will be takes place and by this in by this the greater percentage of drug greater percentage of drugs are excreted out is is created out so due to this excretion of greater percentage of the drug are excreted so there less chance of toxicity in case of this first order elimination and if we discuss about this gene order so in this zero order when all these protein bind so all these proteins which are present inside the bodies are protein binding molecule are saturated so and after this even when increase further increase dose of drug we if further we increase the dose of drug we if further we increase the dose of drug in the body then it is elimination is not increased.

03:04 Elimination is not increase in this case.

03:13 So we can say they are only a constant amount is going to be excreted out.

03:20 So here the more chance of toxicity.

03:26 So in this zero order there are the saturation will be taking place.

03:31 So in this first answer, the zero order kinetics regarding the also option two where the saturation will be takes place in this case.

03:40 So option two is the right answer for this question.

03:43 Similarly, the second part of the question is given...

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