In liver cells, what is the possible fate of acetyl-CoA produced from the oxidation of a fatty acid? Both oxidation via the citric acid cycle and use in ketone body production Use in gluconeogenesis Oxidation via the citric acid cycle Use in ketone body production
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Step 1: Fatty acids undergo beta-oxidation in liver cells, producing acetyl-CoA. Show more…
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When acetyl-CoA produced by beta-oxidation in the liver exceeds the capacity of the TCA cycle to use acetyl-CoA, the excess acetyl-CoA is used to form ketone bodies. High rates of ketogenesis are observed in severe uncontrolled diabetes because the tissues cannot use glucose and must use fats for energy instead. What problems would occur if the liver did not divert acetyl-CoA to ketones? How does the diversion to ketone bodies solve the problem?
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What is the outcome of the accumulation of acetyl-CoA in the mitochondria of the liver? It is used as an energy source. It is broken down into free fatty acids. It gets converted to oxaloacetate. It forms ketone bodies. It is transported to the blood.
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Describe the metabolic pathway of $\beta$ -oxidation; calculate the ATP from the complete oxidation of a fatty acid. When are ketone bodies produced in the body?
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