Question 8 Regarding protein subunits that interact specifically with DNA sequences, which of the following statements is correct? A) They typically recognize sequences of two to three nucleotide pairs in length. B) They do so via hydrogen bonds, ionic bonds, and hydrophobic interactions. C) They typically form about five weak interactions at the protein-DNA interface. D) They often bind loosely to DNA. 1 Point
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Step 1: Protein subunits that interact specifically with DNA sequences are called transcription factors. Show more…
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Parts of proteins that interact specifically with DNA sequences generally have which of the following characteristics. They do so via hydrogen bonds ionic bonds and hydrophobic interactions. They typically form about five weak interactions at the protein-DNA interface. They typically recognize sequences of two to three nucleotide pairs in length. All of the others. They often bind loosely to DNA.
Babar A.
Activator or repressor proteins which bind DNA to regulate the transcription of genes do so mainly by: A. Covalent interactions between the protein and specific bases in the major groove of DNA B. Covalent interactions of Zn2 atoms with the phosphodiester backbone C. Non-covalent interactions between the protein and specific bases in the major groove of DNA D. Covalent interactions with nearby nucleosomes E. Answers B and D are correct
Sri K.
Explain how DNA-binding proteins can make sequence-specific contacts to a double-stranded DNA molecule without breaking the hydrogen bonds that hold the bases together. Indicate how, through such contacts, a protein can distinguish a T-A from a C-G pair. Indicate the parts of the nucleotide base pairs that could form noncovalent interactions hydrogen bonds, electrostatic attractions, or hydrophobic interactions (see Panel $2-3$ pp. $70-71)-$ with a DNA-binding protein. The structures of all the base pairs in DNA are given in Figure $5-4$
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