Question

Question 2 Angie lost her mother, grandmother, and aunt to cancer. She does not have cancer, but because of her history, she takes a genetic test that shows she has a cancer-promoting mutation in the gene BRCA1 that was inherited from one of her parents. The BRCA1 protein helps repair damaged DNA. One of her breast cells then acquires a second mutation in the gene p53. She then has three biological children: two daughters and a son. The father, Bradley, does not carry either mutation. A. Given the role of the BRCA1 protein in the cell, why do mutations in BRCA1 promote cancer? Explain. (roughly two sentences) B. How many different alleles of BRCA1 does Angie have in the nucleus of one of her breast cells? Explain your answer in terms of homologous chromosomes. (roughly two sentences) C. Which of Angie's cells carries a mutated allele of BRCA1? (roughly two sentences) D. What is the probability that Angie passed on her BRCA1 mutation to her son? (roughly three sentences) E. What is the probability that Angie passed on her p53 mutation to her oldest daughter?

          Question 2
Angie lost her mother, grandmother, and aunt to cancer. She does not have cancer, but
because of her history, she takes a genetic test that shows she has a cancer-promoting
mutation in the gene BRCA1 that was inherited from one of her parents. The BRCA1 protein
helps repair damaged DNA. One of her breast cells then acquires a second mutation in the gene
p53. She then has three biological children: two daughters and a son. The father, Bradley, does
not carry either mutation.
A. Given the role of the BRCA1 protein in the cell, why do mutations in BRCA1 promote
cancer? Explain. (roughly two sentences)
B. How many different alleles of BRCA1 does Angie have in the nucleus of one of her
breast cells? Explain your answer in terms of homologous chromosomes. (roughly two
sentences)
C. Which of Angie's cells carries a mutated allele of BRCA1? (roughly two sentences)
D. What is the probability that Angie passed on her BRCA1 mutation to her son? (roughly
three sentences)
E. What is the probability that Angie passed on her p53 mutation to her oldest daughter?

Question 2
Angie lost her mother, grandmother, and aunt to cancer. She does not have cancer, but
because of her history, she takes a genetic test that shows she has a cancer-promoting
mutation in the gene BRCA1 that was inherited from one of her parents. The BRCA1 protein
helps repair damaged DNA. One of her breast cells then acquires a second mutation in the gene
p53. She then has three biological children: two daughters and a son. The father, Bradley, does
not carry either mutation.
A. Given the role of the BRCA1 protein in the cell, why do mutations in BRCA1 promote
cancer? Explain. (roughly two sentences)
B. How many different alleles of BRCA1 does Angie have in the nucleus of one of her
breast cells? Explain your answer in terms of homologous chromosomes. (roughly two
sentences)
C. Which of Angie's cells carries a mutated allele of BRCA1? (roughly two sentences)
D. What is the probability that Angie passed on her BRCA1 mutation to her son? (roughly
three sentences)
E. What is the probability that Angie passed on her p53 mutation to her oldest daughter?

Added by Thomas P.

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