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Question: Describe the process of protein synthesis using the example of cystic fibrosis. Explain why a cell in a person with cystic fibrosis does not make a working CTFR protein during the process of protein synthesis leading to changes in the mucous layer that lines the insides of important tissues. Make sure to describe EACH step of protein synthesis using vocabulary, concepts, and cell organelles we have learned this week and previous weeks in this class. Cystic Fibrosis. (for this assignment you really just need to read the small "The Affected Gene section" and then use this example to explain protein synthesis) HINTS: • Think about where the mistake first appears • Follow that mistake all the way to the non-working CTFR protein through the process of protein synthesis. • Explain each step of protein synthesis along the way: what is happening, where it is happening, why it is happening, using vocabulary, processes and cell organelles in your explanation • Remember the focus is on explaining the process of protein synthesis using this protein/trait as an example. Stick to the process!

          Question: Describe the process of protein synthesis using the example of cystic
fibrosis. Explain why a cell in a person with cystic fibrosis does not make a working CTFR protein
during the process of protein synthesis leading to changes in the mucous layer that lines the insides
of important tissues. Make sure to describe EACH step of protein synthesis using vocabulary, concepts, and
cell organelles we have learned this week and previous weeks in this class.
Cystic Fibrosis. (for this assignment you really just need to read the small "The Affected Gene section" and
then use this example to explain protein synthesis)
HINTS:
• Think about where the mistake first appears
• Follow that mistake all the way to the non-working CTFR protein through the process of protein
synthesis.
• Explain each step of protein synthesis along the way: what is happening, where it is happening, why it
is happening, using vocabulary, processes and cell organelles in your explanation
• Remember the focus is on explaining the process of protein synthesis using this protein/trait as an
example. Stick to the process!

Show more…

Question: Describe the process of protein synthesis using the example of cystic
fibrosis. Explain why a cell in a person with cystic fibrosis does not make a working CTFR protein
during the process of protein synthesis leading to changes in the mucous layer that lines the insides
of important tissues. Make sure to describe EACH step of protein synthesis using vocabulary, concepts, and
cell organelles we have learned this week and previous weeks in this class.
Cystic Fibrosis. (for this assignment you really just need to read the small "The Affected Gene section" and
then use this example to explain protein synthesis)
HINTS:
• Think about where the mistake first appears
• Follow that mistake all the way to the non-working CTFR protein through the process of protein
synthesis.
• Explain each step of protein synthesis along the way: what is happening, where it is happening, why it
is happening, using vocabulary, processes and cell organelles in your explanation
• Remember the focus is on explaining the process of protein synthesis using this protein/trait as an
example. Stick to the process!

Added by Jeanette F.

Biology for AP Courses

Julianne Zedalis, John Eggebrecht

Instant Answer

Solved by Expert Supreeta N

12/14/2023

Step 1

The affected gene in cystic fibrosis is the CFTR gene, which encodes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. During transcription, the CFTR gene is transcribed into a messenger RNA (mRNA) molecule in the nucleus of the cell. Show more…

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Question: Describe the process of protein synthesis using the example of cystic fibrosis. Explain why a cell in a person with cystic fibrosis does not make a working CTFR protein during the process of protein synthesis leading to changes in the mucous layer that lines the insides of important tissues. Make sure to describe EACH step of protein synthesis using vocabulary, concepts, and cell organelles we have learned this week and previous weeks in this class. Cystic Fibrosis. (for this assignment you really just need to read the small "The Affected Gene section" and then use this example to explain protein synthesis) HINTS: Think about where the mistake first appears Follow that mistake all the way to the non-working CTER protein through the process of protein synthesis. Explain each step of protein synthesis along the way: what is happening, where it is happening, why it is happening, using vocabulary, processes and cell organelles in your explanation Remember the focus is on explaining the process of protein synthesis using this protein/trait as an example. Stick to the process! Question: Describe the process of protein synthesis using the example of cystic fibrosis. Explain why a cell in a person with cystic fibrosis does not make a working CTFR protein during the process of protein synthesis leading to changes in the mucous layer that lines the insides of important tissues. Make sure to describe EACH step of protein synthesis using vocabulary, concepts, and cell organelles we have learned this week and previous weeks in this class then use this example to explain protein synthesis) HINTS: Think about where the mistake first appears Follow that mistake all the way to the non-working CTER protein through the process of protein synthesis. Explain each step of protein synthesis along the way:what is happening,where it is happening,why it is happening,using vocabulary, processes and cell organelles in your explanation Remember the focus is on explaining the process of protein synthesis using this protein/trait as an example.Stick to the process!

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00:01 Hello students, the question says that use cftr and the corresponding gene product to illustrate how a typical pancreatic cell accomplishes gene expression and protein localization by describing the following events.

00:20 The first one is organizing and modifying chromatin to make cftr gene available for transcription.

00:30 Cftr is the cystic fibrosis transmembrane regulator.

00:38 So, before the cftr gene can be transcribed, the chromatin structure needs to be modified to make the gene accessible for transcription and translation.

01:13 This is done through a process called chromatin remodeling, which involves the addition or removal of chemical groups on histone proteins that make up the chromatin.

01:43 This modification can either promote or inhibit gene expression.

01:53 The second step we are supposed to tell is regarding the complex required for transcription initiation of cftr gene.

02:06 Once the chromatin has been remodeled and the transcription machinery can access the cftr gene, the complex required for transcription initiation, which includes the rna polymerase ii transcription factors and other regulatory proteins, which constitute the transcription machinery, get access to the cftr gene.

02:54 These all transcription machinery components bind to specific regions of the cftr gene and initiate transcription.

03:20 Another one is processing cftr transcript.

03:23 After the mrna transcript has been transcribed, it undergoes several processing steps, which include splicing, capping, and polyadenylation.

03:45 Splicing removes the introns, while capping and polyadenylation protect mrna from degradation and help it to be transported out of the nucleus into the cytoplasm for translation.

04:07 The next step will be transporting cftr mrna into the cytoplasm from the nucleus...

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