Questions 3-5. The pedigree illustrates a rare trait controlled by a single gene, gene A. Use this information to answer the questions below. 3. What is the genotype of individual III-4? a) 2/3 AA ; 1/3 Aa b) 1/3 AA ; 2/3 Aa c) 1/2 AA ; 1/2 Aa d) 1/3 AA ; 1/3 Aa e) none of the above 4. What is the probability IV-2 is heterozygous? a) 1/2 b) 5/9 c) 1/6 d) 11/18 e) 2/3 5. If IV-1 were to marry IV-2, what is the probability that their first child would be affected with the trait? a) 25% b) less than 1% c) less than 5% d) less than 10%
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Bryan V.
2. The following pedigrees represent the inheritance of two different rare genetic diseases that are 100% penetrant. Answer the following questions for the pedigree on the left. A. Is this disorder inherited in a dominant or recessive fashion? recessive B. Is this trait showing autosomal or sex-linked inheritance? autosomal C. What is the probability that child A will be a carrier of the disease allele? 1/2 x 1/2 = 1/4 D. What is the probability that child B will be a carrier of the disease allele? 100% E. What is the probability that individual C is a carrier of the disease allele? 2/3 Answer these questions for the pedigree on the right. F. What type of inheritance is most likely to account for this pedigree? sex-linked recessive G. What is the probability that child A will show the disease? 1/2 x 1/2 x 1/2 = 1/8 H. What is the probability that individual B is a carrier of the disease allele? 0% I. What is the probability that individual C is a carrier of the disease allele? 100%
Katlin K.
The pedigree below concerns a certain rare disease that is incapacitating but not fatal. a. Determine the most likely mode of inheritance of this disease. b. Write the genotype of each family member according to your proposed mode of inheritance. c. If you were this family's doctor, how would you advise the three couples in the third generation about the likelihood of having an affected child?
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