Question

Rachel is studying cholesterol synthesis in mice. Some mice had a mutation in their sterol regulatory element binding protein (SREBP) that is normally active when cholesterol levels are low in the cell. This mutation can no longer bind to the gene promoter for cholesterol synthesis pathway enzyme HMG-CoA reductase. What would happen to HMG-CoA reductase levels? Again, identify this type of effect and briefly define it.

Name: rachel is studying cholesterol synthesis in mice some mice had a mutation in their sterol regulatory element binding protein srebp that is normally active when cholesterol levels are low in 52232
Uploaded: 2022-02-04T03:43:49-08:00
Duration: 2 min 42 s
Channel: Bryan Valdivia
Description: rachel is studying cholesterol synthesis in mice some mice had a mutation in their sterol regulatory element binding protein srebp that is normally active when cholesterol levels are low in 52232

          Rachel is studying cholesterol synthesis in mice. Some mice
had a mutation in their sterol regulatory element binding protein
(SREBP) that is normally active when cholesterol levels are low in
the cell. This mutation can no longer bind to the gene promoter for
cholesterol synthesis pathway enzyme HMG-CoA reductase. What would
happen to HMG-CoA reductase levels?   Again, identify
this type of effect and briefly define it.

Added by Kara J.

Biology for AP Courses

Julianne Zedalis, John Eggebrecht

Instant Answer

Solved by Expert Bryan Valdivia

02/04/2022

Step 1

To understand the effect of the mutation on HMG-CoA reductase levels, let's break down the process: Show more…

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Rachel is studying cholesterol synthesis in mice. Some mice had a mutation in their sterol regulatory element binding protein (SREBP) that is normally active when cholesterol levels are low in the cell. This mutation can no longer bind to the gene promoter for cholesterol synthesis pathway enzyme HMG-CoA reductase. What would happen to HMG-CoA reductase levels? Again, identify this type of effect and briefly define it.