Rank the following carbonyl-containing compounds in order of reactivity towards nucleophilic acyl substitution. Most reactive Least reactive acetyl chloride acetic propionic anhydride hexyl propanoate benzamide
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Acetyl chloride: This compound is an acyl chloride, which is the most reactive among carboxylic acid derivatives towards nucleophilic acyl substitution. This is because chloride is a good leaving group and the carbonyl carbon is highly electrophilic. Show more…
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