Rank the following carbonyl-containing compounds in order of reactivity towards nucleophilic attack. Most reactive acetyl chloride propionamide benzoic anhydride isopropyl benzoate acetaldehyde propanone Least reactive
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Acyl halides (such as acetyl chloride) are the most reactive carbonyl compounds towards nucleophilic attack due to the highly polarized C-X bond (X = halogen) and the excellent leaving group (Cl-). So, acetyl chloride is the most reactive. Show more…
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