Regions to be transcribed.
This chromatin remodeling is accomplished through the release of histone proteins by competition with other nuclear proteins, enzymatic degradation of histone proteins, chemical modification of histone proteins, the release of histone proteins by DNA helicase, and chemical modifications to the DNA that weaken histone association.
Regulation in eukaryotes involves reorganization of the chromatin structure such that DNA binding is weakened in regions to be transcribed.