Question

Remember that cancer involves the loss of control of the cell cycle. This can happen in a variety of ways, but can often involve a change in a tumor suppressor gene or in a proto-oncogene. Considering the differences between these control mechanisms, discuss whether the following proteins are likely to come from a tumor suppressor gene or from a proto-oncogene. Justify each response in a manner worthy of 4 points. The articulation of your reasoning is just as important as the correct answer. Proteins involved in signaling pathways that activate proliferation (cell division) A protein that recognizes and fixes double-strand breaks in DNA A specific transcription factor that represses the promoters of genes involved in cell proliferation A protein that initiates apoptosis (programmed cell death)

          Remember that cancer involves the loss of control of the cell
cycle. This can happen in a variety of ways, but can often involve
a change in a tumor suppressor gene or in a proto-oncogene.
Considering the differences between these control mechanisms,
discuss whether the following proteins are likely to come from a
tumor suppressor gene or from a proto-oncogene. Justify each
response in a manner worthy of 4 points. The articulation of
your reasoning is just as important as the correct answer.
 Proteins involved in signaling pathways that activate
proliferation (cell division)
 A protein that recognizes and fixes double-strand breaks
in DNA
 A specific transcription factor that represses the
promoters of genes involved in cell proliferation
 A protein that initiates apoptosis (programmed cell
death)

Added by Daniel F.

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