Rheumatic fever can occur as a serious complication of inadequately treated strep throat and scarlet fever. It may occur from two to four weeks after a primary GAS infection, and in some cases causes significant heart damage. Which of the following represents the most reasonable explanation for why this occurs? Choose one:A. The antibodies made against S. pyogenes are ineffective against this bacterium.B. S. pyogenes exotoxins take a long time to reach the heart. C. Drugs such as amoxicillin that are used to treat strep throat are only bacteriostatic (not bactericidal). D. Certain proteins on heart valves bear similarities to S. pyogenes antigens.
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Rheumatic fever is a complication that can arise after an infection with Group A Streptococcus (GAS), which causes strep throat and scarlet fever. It typically occurs 2 to 4 weeks after the initial infection. Show more…
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Streptococcal pharyngitis (strep throat) involves all the following except: purulent exudate over the tonsils can lead to serious complications such as rheumatic fever can lead to scarlet fever if it is an erythrogenic toxin-producing strain is usually caused by the alpha-hemolytic streptococci the pathogen produces a virulence factor, M protein, that shows characteristics of molecular mimicry Class I MHC receptors are: receptors for "self" antigens or intracellular antigens (such as viral antigens and tumor antigens) checked and recognized by cytotoxic T lymphocytes involved in organ rejection diverse among individuals in the population and need to be matched during organ transplant all of the choices are correct not located on red blood cells
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A. Explain how Streptococcus pyogenes is diagnosed by throat culture on a Sheep Blood Agar Plate. Please be specific. B. A disease can be related to untreated Streptococcus pyogenes infections, Rheumatic fever. What are the symptoms of this disease? A popular theory of this disease is that antibodies are produced against Streptococcus pyogenes that are very similar in specificity to that of the valves of the heart. Why would this affinity be a problem (Hint: What might be activated?)?
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Your patient is a 15-year-old boy with migratory polyarthritis, fever, and a new, loud cardiac murmur. You make a clinical diagnosis of rheumatic fever. Which one of the following modes of pathogenesis is most compatible with this diagnosis? a. Bacteria attach to joint and heart tissue via pili, invade and cause inflammation b. Bacteria cause violent destructive infection of heart valves c. Bacteria secrete exotoxins that circulate via the blood to the joints and heart d. Bacterial antigens induce antibodies that cross-react with joint and heart tissue e. Bacterial endotoxin induces IL-1 and TNF, which causes inflammation in joint and heart tissue.
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