Ribosomes can be either free in the cytosol or bound...

Ribosomes can be either free (in the cytosol) or bound (attached to the rough ER). Consider the list of proteins below and determine which would be synthesized by a bound ribosome. Hint #1: Remember that free ribosomes synthesize proteins that will remain in the cytosol or travel to the nucleus. Bound ribosomes synthesize proteins that will be used within the endomembrane system or be secreted from the cell - for example proteins destined for the cell membrane, the extracellular matrix, or for destinations outside the cell (e.g., hormones, neurotransmitters). Hint #2: Look up the functions of the proteins below and determine their destination. GLUT2 BRCA1 primase topoisomerase LDLR collagen

Transcript

00:01 Okay, i want to answer this question and talk about proteins and indices, okay? remember that if this is your cell and this is the nucleus of your cell, first in order to produce a protein, you're going to have your dna here, and you're going to have a gene for that protein.

00:14 This gene is going to be expressing, and it's going to produce an mrna, and this amaranase going to be, it's going to move out of the nucleus, and then it's going to get to a cytoclasm.

00:25 Now, depending on which protein you're going to produce from this gene, you can follow two pathways.

00:32 If the protein that you want to produce is going to work for this same cell, then you're going to, or this ammarinase going to bind to ribosomes that are free in the cytoplasm.

00:42 And you're going to produce your protein, and that's it.

00:44 Okay? but if you want to produce a protein that needs to be secreted out of the cell or attached to the membrane of the cell, then this amaranate going to bind two fibosomes that are attached to the surface of this, organelle that is the goph endoplasmic reticulum.

01:01 So here i'm going to touch your mna and your mran is going to get to the gophonoplasmic reticulum.

01:06 Then it is going to be released in vesicles to another organelle that is called the golgi apparatus.

01:12 And here this protein is going to undergo many modifications.

01:16 And then it is going to be released again in vesicles to the extracellular part of the cell.

01:22 Okay.

01:23 So this is what these are two different pathways, as you can see here.

01:29 This question practically says, consider the list of proteins below in the termine which would be synthesized by a bound of ribosome.

01:37 It means it says hint number one, remember that three ribosomes synthesized proteins that will remain in the cytosol as we stated here or travel to the nucleus.

01:47 Bound of ribosomes, it means these guybosomes here, synthesized proteins that will be used within the end of membrane system or be secreted from the cell.

01:55 Okay.

01:57 So the proteins that they are giving us are going to be this, including so first we have this gluten protein.

02:05 This is a surface, particularly it is an ion channel that is attached on the cell membrane.

02:11 So as it is going to be attached here, then it is going to be, or the mri for this protein is going to be synthesized by a bound of bio -o.

02:19 So this is correct.

02:21 Now let's go for brca1...