00:01
The correct answer is option number b which is catalytic excision of sections of ribosomal rna.
00:12
The ribosomal rna or rrna is essential for the functioning of ribosomes.
00:19
It is essential for ribosome functioning.
00:23
Ribosome functioning which are cellular structures that are responsible for protein synthesis.
00:32
Specifically, there are two subunits of ribosomes, the small and the large subunits.
00:38
The large and small subunits and they consist of both rna and protein compound.
00:49
The recents toxicity is linked to its ability to interfere with protein synthesis which is crucial for cell survival and function.
00:58
So by damaging rrna, the recin disrupts the process of protein synthesis.
01:23
So why and how recin does this is by the following method.
01:27
First that it binds to the cell surface.
01:32
First that it binds to the cell surface.
01:38
Cell surface through the receptor mediated endocytosis.
01:45
It binds to the specific glycoprotein receptors in the cell surface which allows its internalization.
01:53
Then they get internalized after binding to the cell.
01:59
Then in the next step, there is intracellular transport.
02:06
Intracellular transport.
02:10
So after internalization, the recin is transported to the endoplasmic reticulum of the cell.
02:16
So recin reaches the endoplasmic reticulum of the cell.
02:20
Then there is recin a -chain activity.
02:24
Recin consists of two chains, the a -chain and the b -chain.
02:29
A -chain and the b -chain.
02:32
And the a -chain contains the catalytic activity which is responsible for toxic effects.
02:48
Which is responsible for the toxic effects...