Role of c-myc in human cancer and n-myc gene in human cancer
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MYC proto oncogene or tumor suppressor?
Dr. Anas S.
The myc gene codes for the MYC protein, which functions as an activator of gene transcription. High levels of MYC expression have been documented in about 70% of human cancers. a. Based on this information, would you classify the myc gene as an oncogene or a tumor suppressor gene? Briefly explain your reasoning. b. What types of genes (in terms of their protein products) would be the target of the MYC protein?
Madhur L.
Overexpression of Myc protein is a common feature of many types of cancer cells, contributing to their excessive growth and proliferation. By contrast, when Myc is overexpressed in most normal cells, the result is not excessive proliferation, but cell cycle arrest or apoptosis. How do you suppose that overexpression of Myc can have such different outcomes in normal cells and in cancer cells?
Melanie M.
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