Rotenone is a toxic natural product from plants that strongly inhibits NADH dehydrogenase. Antimycin A is a toxic antibiotic that strongly inhibits the oxidation of ubiquinol. a) Explain the mechanistic basis for the toxicity of these molecules. b) Which of these would be a more potent poison? Explain.
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By inhibiting this enzyme, rotenone blocks the transfer of electrons from NADH to ubiquinone in Complex I of the ETC. This leads to a buildup of electrons in the ETC and a decrease in the production of ATP through oxidative phosphorylation. Show more…
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