Sample Problems 1. A liver biopsy of a boy indicate a...

Sample Problems 1. A liver biopsy of a boy indicate a deficiency of fructose-1,6-bisphosphatase activity. The boy's blood glucose levels were normal at a beginning of a fast but decreased precipitously. Pyruvate and alanine levels increased and the glyceraldehyde-3phosphate/dihydroxyacetone phosphate ratio increased as well. Why did these symptoms occur? 2. If the oxidation of glucose-6-phosphate via the pentose phosphate pathway were being used primarily to generate NADPH for biosynthesis, the other product, ribose-5-phosphate, would accumulate. What problems might this cause? 3. Many bacterial species can carry out the reactions of gluconeogenesis. Would you expect to find the gluconeogenic enzyme glucose-6-phosphatase in such bacteria? Why or why not?

Transcript

00:01 Hello everyone.

00:02 Here the question says a liver biopsy of a boy indicate deficiency of fructose 1 6 bisphosphate.

00:09 So, proctose 1 6 bisphosphate is what it is? it is an enzyme.

00:35 And this is deficient in a boy and there are symptoms due to this deficiency.

00:42 See one is increased level of pyruid and aline and the other symptom is decreased level of glucose so why these symptoms appear in the boy okay so we have to tell this so this is an enzyme it has a very important role in two processes taking place in our body one is glycolysis okay it's playing role in glycolysis and another one is gluconeogenesis gluconeogenesis okay if we talk about these two processes then glycolysis is the breakdown of glucose for the production of energy okay like in respiration there is a breakdown of glucose and where this enzyme is required and another process is glyco gluconeogenesis here this enzyme playing very significant role and gluconeogenesis is the reversal of glycolycolysis is the reversal of glycolysis that means there is a production of glucose here glucose is formed from pyruid here glucose is formed when there is deficiency of glucose in the body then glycognogenesis process is taking place with the help of this fructose 1 6 bisphosphate and their glucose is formed from two products like pyruid and alenine okay so in the question they are saying that fructose 1 6 bis phosphate is deficient so now these two processes are not taking place in the body and majorly this process is not going to be happen in the body so now the result will cause the accumulation of pyruid and aline in the body.

03:22 So this will lead to the accumulation of these two.

03:33 If this enzyme is deficient, then this pyruid and alenine will accumulate in the body and result in increase in level of pyruid and alenine...

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