035 (Select all that apply) Which of the following are correct about the structure and function of the TATA-binding protein (TBP)? TBP binds to the major groove of the DNA. TBP directly recruits RNA Polymerase II to the promoter. TBP recognizes the TATA box sequence. TBP causes a bend in the DNA upon binding. TBP is part of the TFIID complex. Save Answer Q36 (Select all that apply) Which of the following statements about the evolution of splicing mechanisms are supported by the evidence? The diversity of splicing mechanisms in different organisms and cellular compartments supports the idea of multiple independent origins of introns The similarities between group I introns and DNA/RNA polymerases suggest a common evolutionary origin for these systems Group I introns represent an evolutionary intermediate between self-splicing group II introns and the spliceosome The spliceosome evolved from ancestral group II introns, with snRNAs replacing the catalytic domains of the intron Save Answer Q37 (Select all that apply) Which of the following are involved in stabilizing the codon-anticodon interaction in the ribosomal A site? 16S rRNA bases (in bacteria) Elongation factor EF-Tu (in bacteria) Ribosomal proteins A minor interactions with rRNA bases at all positions of the codon Save Answer Q38 (Select all that apply) Which statements about the interactions between gene-specific transcription factors and DNA are correct? Zinc finger domains only recognize RNA sequences. All gene-specific transcription factors directly interact with RNA Polymerase II. Leucine zipper motifs facilitate dimerization of transcription factors. Helix-turn-helix domains typically bind the major groove of DNA. Gene-specific transcription factors can recruit coactivators like CBP/p300.
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It is a component of the TFIID complex, which is a general transcription factor that is required for the initiation of transcription by RNA polymerase II. Show moreā¦
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TBP (TATA binding protein) is a subunit of TFIID. TBP binds to the TATA box within the eukaryotic gene promoter. Why can TBP be considered an INDIRECT positioning factor for RNA polymerase, affecting the correct location of transcription initiation? Circle all that are true, or mark e if all are true. A) If TBP doesn't bind to the TATA box, TFIID won't be positioned properly, and TFIID has other proteins within it that regulate transcription initiation, called TAFs (TBP-associated factors). B) TBP recruits TFIIA and TFIIB to the promoter. C) TFIIB recruits RNA polymerase II and TFIIF to the promoter. D) If TBP didn't bind to the TATA box properly, TFIIB wouldn't be recruited to the promoter at the correct location, and thus recruit RNA polymerase II to the promoter at the correct location. This is why when the TATA box was mutated, scientists got not only a little bit of the correct length RNA transcripts but also shorter ones because transcription didn't initiate at the correct location. E) All of the above are true.
Shaiju T.
Structure and function in biology result from both the presence of genetic information and the expression of that information. Some genes are continually expressed, whereas the expression of most genes is regulated, commonly at the level of transcription. At the initiation of transcription, the TATA-binding protein (TBP) provides access to the DNA strand to be transcribed. The 5āTATAAA3ā sequence called the TATA box is found in prokaryotes, archaebacteria, and eukaryotes. Even among eukarya, when the TATA box is not present among eukaryotes, the initiation of transcription involves TBP. Scientists attribute this common characteristic to the relative thermostability of the A-T interaction. Hydrogen bonds hold the two strands of the DNA double helix together. This type of bond has the smallest interaction energy of all intermolecular forces; as temperature increases, these bonds are broken. A. Explain the advantage, in terms of the energy required, which is provided by an AT-rich region in the sequence where transcription is initiated. B. The fact that the TATA box or the associated TBP are common to all domains provides evidence of common ancestry among all life. Pose a scientific question that would need to be addressed by a valid alternative explanation of this fact. C. A whole-genome survey of prokaryotes (Zheng and Wu, BMC Bioinformatics, 2010) showed that the relative amounts of guanine and cytosine in DNA poorly predicted the temperature range conditions that are suitable for an organism. Refine the question posed in part B, taking this result into account.
1. The TATA-binding protein (TBP) binds to the TATA box sequence in eukaryotic promoters. What is its function in transcriptional initiation? Select one: a. It blocks access of RNA polymerase to the promoter, until removed by general transcription factors. b. It is the subunit of prokaryotic RNA polymerase that is required to recognize promoters. c. It modifies histones so that nucleosomes can be removed from DNA for transcription. d. It bends and partly unwinds DNA at a promoter. e. It creates a phosphodiester bond between the nucleotides. 2. A linear DNA fragment is cut with a restriction enzyme to yield two fragments. How many restriction sites are there for the enzyme in this fragment? Select one: a. 1 b. 2 c.3 d. 4 e. Cannot be determined with this information. 3. A _______________ allows us to predict the value of one variable from the value of a correlated variable. Select one: a. regression b. covariance c. correlation d. variance e. standard deviation
Dominador T.
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