select the events that must occur for inherited retinoblastoma to develop and individual must have two mutated copies of the rb gene
Added by Paul R.
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Step 1: Inherit a mutated RB allele (germline mutation) present in all cells, including retinal cells. Show more…
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1. Select the events that must occur for inherited retinoblastoma to develop. Check all that apply. The cell proceeds uncontrolled through cell division. The p53 gene must be mutated. An individual must have two mutated copies of the Rb gene. E2F is no longer regulated by Rb.
Adi S.
Define the "two-hit hypothesis" for retinoblastoma. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Not all terms will be used. sporadic retinoblastoma hereditary retinoblastoma only one copy both copies Part B Explain why cancer is almost certain to develop with the inheritance of one mutated copy of RB1. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Not all terms will be used. G1 to S phase G2 to M phase no functional copies only one functional copy
Madhur L.
Sporadic cases of retinoblastoma require A One inactivating somatic mutation in one copy of Rb. B Two somatic inactivating mutations, one in each of the two copies of Rb. C One somatic mutation in Rb, leading to its activation. D Two somatic mutations in a copy of Rb, leading to its activation. E None of the above.
Sri K.
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