Several scenarios are described in the questions below. For each scenario, determine whether or not the change described would contribute to uncontrolled cell division (i.e., cancer). Answer choices [A or B] may be used more than once or not at all. 24. A mutant CDK that is active in the absence of its cyclin binding partner. a. This would contribute to uncontrolled cell division. b. This would not contribute to uncontrolled cell division. 25. A defective cyclin that cannot bind to its CDK. a. This would contribute to uncontrolled cell division. b. This would not contribute to uncontrolled cell division. 26. A loss of function mutation in an enzyme that is normally needed for microtubule synthesis/polymerization. a. This would contribute to uncontrolled cell division. b. This would not contribute to uncontrolled cell division.
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Normally, cells exhibit what we call density-dependent inhibition, which inhibits cell division when too many cells are present in a given area (high density). A mutation in what type of gene(s) could lead to a malfunction of this process, and possibly to cancer? Select one: a. Tumour suppressing genes or oncogenes could be mutated, resulting in the cell cycle being stopped at check points. b. A gene coding for the enzyme responsible for the duplication of DNA. c. Tumour suppressing genes or oncogenes could be mutated, resulting in the cell cycle not being stopped at checkpoints. d. A gene coding for proteins of the mitotic spindle.
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Which of the following is the most likely effect of a mutation in the gene coding for a DNA repair enzyme? - The cell containing the mutation will divide more frequently because the cell cycle checkpoints will not function properly. - Mutations will accumulate more quickly because the cell will not be able to fix errors in replication. - The mutated gene will not be transcribed because RNA polymerase cannot transcribe mutated DNA. - The cell will immediately undergo apoptosis so that mutated DNA is not replicated in future rounds of cell division.
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