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Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule. Recall that hemoglobin carries oxygen in your red bloods cells. The mutation causes the red blood cells to become stiff and sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and increased risk of stroke, blindness, damage to the heart and lungs, and other conditions. Below are partial sequences for a normal and sickle cell hemoglobin. Discuss how they are different and explain why one seemingly “minor” change could have such drastic consequences. Normal hemoglobin A.A. sequence VALINE-HISTIDINE-LEUCINE-THREONINE-PROLINE-GLUTAMIC ACID-GLUTAMIC ACID Sickle cell hemoglobin A.A. sequence VALINE-HISTIDINE-LEUCINE-THREONINE-PROLINE-VALINE-GLUTAMIC ACID

          Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the
hemoglobin molecule. Recall that hemoglobin carries oxygen in your red bloods cells. The
mutation causes the red blood cells to become stiff and sickle-shaped when they release their
oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and increased risk of
stroke, blindness, damage to the heart and lungs, and other conditions.
Below are partial sequences for a normal and sickle cell hemoglobin. Discuss how they are
different and explain why one seemingly “minor” change could have such drastic consequences.

Normal hemoglobin A.A. sequence
VALINE-HISTIDINE-LEUCINE-THREONINE-PROLINE-GLUTAMIC ACID-GLUTAMIC
ACID
Sickle cell hemoglobin A.A. sequence
VALINE-HISTIDINE-LEUCINE-THREONINE-PROLINE-VALINE-GLUTAMIC ACID

Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the
hemoglobin molecule. Recall that hemoglobin carries oxygen in your red bloods cells. The
mutation causes the red blood cells to become stiff and sickle-shaped when they release their
oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and increased risk of
stroke, blindness, damage to the heart and lungs, and other conditions.
Below are partial sequences for a normal and sickle cell hemoglobin. Discuss how they are
different and explain why one seemingly “minor” change could have such drastic consequences.

Normal hemoglobin A.A. sequence
VALINE-HISTIDINE-LEUCINE-THREONINE-PROLINE-GLUTAMIC ACID-GLUTAMIC
ACID
Sickle cell hemoglobin A.A. sequence
VALINE-HISTIDINE-LEUCINE-THREONINE-PROLINE-VALINE-GLUTAMIC ACID

Added by Dave F.

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