Some nerve agents have been used as bioweapons. Unfortunately, Sarin gas has been used as a bioweapon several times in other countries. Sarin is an acetylcholinesterase (AChE) inhibitor and even exposure to low levels can be fatal. Based on your knowledge of muscle physiology, why do you think Sarin has these effects?
Added by Laura K.
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Step 1: Sarin is an acetylcholinesterase (AChE) inhibitor, which means it prevents the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. Show more…
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Sarin, a nerve gas, was released into the Tokyo subway system in 1995, injuring more than 5000 people. Sarin blocks the active sites of the enzyme acetylcholinesterase, which degrades acetylcholine, a compound that causes muscles to contract. Over-contraction of muscles can cause asphyxiation. What is the biological term for this nerve gas? Cofactor. Allosteric Inhibitor. Competitive Inhibitor Coenzyme. Activator. Binding site.
Sri K.
Sarin gas is an extremely toxic compound sometimes used as a chemical weapon because exposure and inhalation can be lethal. Sarin gas inhibits the effect of acetylcholinesterase, which is essential for normal function of skeletal muscle. What effect would this have on skeletal muscle function? Skeletal muscles could not undergo tetanus. Skeletal muscles could not initiate action potential. Skeletal muscles could not relax. Skeletal muscles could not release calcium from the sarcoplasmic reticulum. Skeletal muscles could not contract.
Adi S.
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