Some secretory proteins and some integral membrane proteins must pass through a membrane. A ribonucleoprotein known as the signal recongition particle SRP guides these proteins either to the plasma membrane in bacteria or the endoplasmic reitculum in eukaryotes
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Step 1: The ribosome synthesizes a secretory or integral membrane protein, and during this process, a signal peptide is produced at the N-terminus of the growing polypeptide chain. Show more…
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Some secretory proteins and some integral membrane proteins must pass through a membrane. A ribonucleoprotein known as the signal recognition particle (SRP) guides these proteins either to the plasma membrane (in bacteria) or the endoplasmic reticulum (in eukaryotes). Put the following steps of the membrane translocation of eukaryotic secretory proteins in order, starting after the signal peptide emerges from the ribosome and ending with the protein being transported by vesicles out of the endoplasmic reticulum. Signal peptide exits ribosome during translation. Translation resumes. Signal peptidase removes signal peptide from growing polypeptide. SRP binds to the signal peptide, and translation stops. Ribosome docks to a translocon. Growing polypeptide crosses the ER membrane through translocon. SRP moves the ribosome to the ER membrane. The remainder of the polypeptide is moved into the ER lumen. Protein is transported out of the ER.
Adi S.
10. The type of RNA that is an important structural component of the protein-synthesizing system of the cell is a. mRNA b. pre-mRNA c. rRNA d. all of the above 11. The genetic code is conventionally written as _________ (rather than DNA) because this is the molecule with which the translation process occurs. a. DNA b. mRNA c. rRNA d. tRNA 12. The endoplasmic reticulum is a. a network of membranes continuous with the nuclear membrane b. continuous with the Golgi apparatus c. located around the nuclear membrane, but is not in actual contact with it d. none of the above 13. Which one of the following groups of proteins contains signals recognized by membrane receptors on the endoplasmic reticulum (ER)? a. Proteins destined for the cell membrane b. Proteins destined for the cytoplasm c. Proteins destined for the nucleus d. Proteins destined for the mitochondria 14. How are proteins shuttled from the ER to the Golgi apparatus? a. Lysosomes b. Peroxisomes c. Phagocytes d. Vesicles
Madhur L.
Organelles: Trace the path of a secreted protein through the various organelles which it will encounter. What might be happening to the protein in each of these organelles? Describe how a secreted protein gets targeted to the secretion pathway during gene expression: Path of a Secretory Protein Through the Endomembrane System. Proteins destined for secretion are made on ribosomes bound to the RER. The proteins move through the endomembrane system and are dispatched from the Golgi apparatus in transport vesicles that move through the cytoplasm and then fuse with the plasma membrane, releasing the protein to the outside of the cell. Examples of secretory proteins are collagen, insulin, and digestive enzymes of the stomach and intestine. In a similar way, proteins destined for a particular cell organelle move to the organelle in transport vesicles that deposit their contents in the organelle by membrane fusion.
Doc T.
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