Sporadic retinoblastoma is often confined to one eye, not both eyes, because homozygous RB1 mutations _(_())_(_())_(_())_(_()). are embryonic-lethal prevent cell division affect only one eye are rare require one other mutation, a 'second-hit' to cause cancer
Added by Sarah H.
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Sporadic retinoblastoma typically occurs in individuals with no family history of the disease and is usually unilateral (affecting one eye). Show more…
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2. Which of the following statements about Retinoblastoma is false? a. Familial retinoblastoma involves inheriting one germline mutation in the Rb gene and acquiring a second mutation later in life. b. In the familial form of the disease, one mutated gene increases the probability that a second mutation will occur. c. In sporadic retinoblastoma, mutations occur in both alleles of the Rb gene in the same retinoblast after birth. d. The mechanism of action of the Rb gene in cancer does not follow the concept of a tumor suppressor gene described by Knudson’s two-hit hypothesis.
Sri K.
Define the "two-hit hypothesis" for retinoblastoma. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Not all terms will be used. sporadic retinoblastoma hereditary retinoblastoma only one copy both copies Part B Explain why cancer is almost certain to develop with the inheritance of one mutated copy of RB1. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Not all terms will be used. G1 to S phase G2 to M phase no functional copies only one functional copy
Madhur L.
Sporadic cases of retinoblastoma require A One inactivating somatic mutation in one copy of Rb. B Two somatic inactivating mutations, one in each of the two copies of Rb. C One somatic mutation in Rb, leading to its activation. D Two somatic mutations in a copy of Rb, leading to its activation. E None of the above.
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