Which of the following is NOT a means of generating diversity in the variable regions of the B cell receptor genes? a. Cleavage at the coding-heptamer RSS junction by RAG-1/2 b. Somatic hypermutation following activation c. Hairpin cleavage by Artemis to generate P nucleotides d. Addition of N nucleotides by TdT e. All of the above generate diversity in the variable regions of the T-cell receptor genes. QUESTION 7 Which of the following accounts for the transition from membrane-bound IgM to secreted IgM upon activation of a B cell? a. CSR b. Affinity maturation c. Alternative splicing of pre-mRNA d. Additional modification of nuclear DNA via RAG-1/2 e. None of the above
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