Question

Suppose you were investigating a newly discovered growth-factor signal-transduction pathway, involving a G-protein-coupled receptor system. When you add GTP$\gamma$S, a nonhydrolyzable analog of GTP, the duration of the hormonal response increased. Why does the response last longer in the presence of GTP$\gamma$S? O G$\alpha$ binds covalently to adenylate cyclase in the presence of GTP$\gamma$S. O GTP$\gamma$S prolongs the G$\alpha$-adenlylate cyclase association because GDP formation cannot occur. O The G$\alpha$-GTP$\gamma$S complex has higher affinity for the $\beta\gamma$ dimer (G$\beta\gamma$) than for adenylate cyclase. O Adenylate cyclase binds to GTP$\gamma$S independently of the G protein. O The G protein in this signal-transduction pathway is defective for nucleotide binding.

          Suppose you were investigating a newly discovered growth-factor signal-transduction pathway, involving a G-protein-coupled receptor system. When you add GTP$\gamma$S, a nonhydrolyzable analog of GTP, the duration of the hormonal response increased.

Why does the response last longer in the presence of GTP$\gamma$S?
O G$\alpha$ binds covalently to adenylate cyclase in the presence of GTP$\gamma$S.
O GTP$\gamma$S prolongs the G$\alpha$-adenlylate cyclase association because GDP formation cannot occur.
O The G$\alpha$-GTP$\gamma$S complex has higher affinity for the $\beta\gamma$ dimer (G$\beta\gamma$) than for adenylate cyclase.
O Adenylate cyclase binds to GTP$\gamma$S independently of the G protein.
O The G protein in this signal-transduction pathway is defective for nucleotide binding.

suppose you were investigating a newly discovered growth factor signal transduction pathway involving a g protein coupled receptor system when you add gtpgammas a nonhydrolyzable analog of g 00045

Added by Charlotte W.

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