Table 1.
able[[Marker,BM1901,BM1905,BM2012],[Crime Scene Sample,BE,BE,AD],[Suspect 1,BE,EE,AB],[Suspect 2,BE,EE,AD],[Suspect 3,BE,BE,AD]]
Table 2. Allele frequencies at each marker in Zoolandia.
able[[Allele,BM1901,BM1905,BM2012],[A,0.03,0.34,0.02],[B,0.25,0.12,0.20],[C,0.51,0.41,0.46],[D,0.18,0.09,0.01],[E,0.03,0.04,0.31]]Three individuals are suspects in the murder of a fellow citizen on the isolated island of Zoolandia. The victim managed to scratch the murderer during the crime and skin cells were lodged under their fingernails (=crime scene sample). Constables were able to extract DNA from the skin cells. They also independently obtained DNA from blood samples from each of the three suspects. The DNA samples were genotyped at three microsatellite markers and the results are presented in table 1, below. If needed the allele frequencies at each of the three markers in the Zoolandia population at large are presented in table 2. Which, if any, of the suspects can be eliminated as the perpetrator of this crime? Explain. Which, if any, of the suspects could be the murderer? How confident can the constables be that the potential match between any suspect and the evidence from the crime scene could not occur by chance within the broader population of Zoolandia? Which two of the following population genetic principles must hold for your conclusions above to be valid?
1. Recombination
2. Linkage Equilibrium
3. Co-dominance
4. Penetrance
5. Hardy Weinberg Equilibrium
Table 1. Marker
BM1901 BE BE BE BE
BM1905
BM2012
Crime Scene Sample
BE BE EE BE
AD AB AD AD
Suspect 1 Suspect 2 Suspect 3
Table 2. Allele frequencies at each marker in Zoolandia Allele BM1901 BM1905 BM2012 A 0.03 0.34 0.02 B 0.25 0.12 0.20 C 0.51 0.41 0.46 D 0.18 0.09 0.01 E 0.03 0.04 0.31