00:01
Hello students, different vasoactive agents can have varied effects on the blood vessel diameter, leading to either vasoconstriction or vasodilation.
00:09
So, here are the effects of some local vasoactive agents on vasoconstriction and vasodilation.
00:17
So first is epinephrine.
00:19
Epinephrine causes vasoconstriction because it binds to the alpha -androgenic receptors on the smooth muscle cells in the vessel walls.
00:32
This leads to the contraction and decreasing in the blood vessel diameter.
00:40
Similarly, the norepinephrine also works like epinephrine, causes vasoconstriction.
00:46
It also binds to the alpha -androgenic receptor on smooth muscle cells of blood vessels and causes vasoconstriction.
00:56
Next one is acetylcholine.
00:58
Acetylcholine causes vasodilation because it primarily acts on the endothelial cell lining of blood vessel and stimulates the release of nitrous oxide from endothelial cell which then diffuses into the smooth muscle cells and induces their relaxation.
01:27
Next one is histamine.
01:29
Histamine is also a vasodilator...