Tamiflu increases the K_(m) value for the substrate compared to the Relenza Relenza increases the V_(max ) value for the substrate compared to Tamiflu Both drugs are competitive inhibitors of the viral enzyme
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The graph below shows kinetic data obtained for flu virus enzyme activity as a function of substrate concentration in the presence and absence of two antiviral drugs. Based on the graph, which of the following statements is correct? A. Both drugs are noncompetitive inhibitors of the viral enzyme. B. Tamiflu increases the $K_{\mathrm{m}}$ value for the substrate compared to Relenza. C. Relenza increases the $v_{\max }$ value for the substrate compared to Tamiflu. D. Both drugs are competitive inhibitors of the viral enzyme.
Which of these is an approximate measure of enzyme-substrate binding affinity? ½ V-max k-cat V-max Km E-tot A competitive inhibitor of an enzyme: decreases Km without altering V-max. increases Km and decreases V-max. increases Km without altering V-max. decreases both Km and V-max.
Madhur L.
Dasatinib and Gleevec are competitive inhibitors of the BCR-ABL fusion protein. Which variable(s) used to describe enzyme activity will remain the same in the presence and absence of a Gleevac and Dasatinib? Km Vmax V Vmax and Km GNF-2 is an allosteric /non-competitive inhibitor that is used when Dasatinib and Gleevec are no longer effective. Why is GNF-2 effective when dasatinib and Gleevec fail? it binds outside of the active site in both active and in-active conformations of the protein it binds in the active site in both active and in-active conformations of the protein it binds the active site more strongly the Gleevec and Dasatinib to inhibit enzyme activity
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