The antimicrobial drugs with the broadest spectrum of activity are __________. O aminoglycosides O chloramphenicol O penicillin G O tetracyclines
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Step 1: The question asks to identify the antimicrobial drugs with the broadest spectrum of activity among the given options: aminoglycosides, chloramphenicol, penicillin G, and tetracyclines. Show more…
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Which of the following is an example of a broad spectrum antibiotic? A. Penicillin G B. Chloramphenicol C. Streptomycin D. Ampicillin
Preeti K.
Sri K.
Erythromycin: acts by inhibition of protein synthesis by binding to the 23S ribosomal RNA molecule in the 50S subunit of ribosomes in susceptible bacterial organisms. Penicillin: kills bacteria by binding the beta-lactam ring to DD-transpeptidase, inhibiting its cross-linking activity and preventing the formation of new cell walls. A bacterial cell without a cell wall is vulnerable to outside water and molecular pressures, causing the cell to die quickly. Kanamycin: Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing mRNA misreading and preventing the bacterium from synthesizing proteins required for growth. Chloramphenicol: Chloramphenicol is an antibacterial with broad activity against gram-positive, gram-negative, and Rickettsia bacteria. It works by interfering with bacterial protein synthesis by binding to ribosomes. Novobiocin: inhibition of the GyrB subunit of the bacterial DNA gyrase enzyme, which is involved in energy transfer. Tetracycline: binds reversibly to the 30S ribosomal subunit in a position that prevents aminoacyl-tRNA from binding to the acceptor site on the mRNA-ribosome complex. Streptomycin: interferes with the function of ribosomes in bacterial cells, the complex molecular machines that create proteins by linking amino acids together. Neomycin: Through irreversible binding to the 30S ribosomal subunit of susceptible bacteria, it inhibits bacterial protein synthesis. Question: Which antibiotics seem to have the broadest spectrum of activity and why?
Adi S.
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