00:01
Okay, this question here says, a clinical case study, a 19 year old college student noticed abdominal cramping in the lower right quadrant, followed by diarrhea, particularly a few hours after eating popcorn, lettuce, or other uncooked vegetables.
00:19
Over the semester, his cramps and diarrhea worsened, and he began having fevers, chills, and weight loss.
00:26
He was referred to a gastroenterologist who ruled out acute appendicitis.
00:31
The doctor ordered an x -ray of the abdomen with a barium contrast, and the radiograph showed the structures of the intestines due to inflammation of the mucosa in the terminal ilium.
00:43
The doctor diagnosed him with inflammatory bowel disease, specifically crohn's disease, because inflammatory bowel disease can include crohn's disease or ulcerative colitis.
00:56
The patient was treated with sulfasalazine, which has both antibacterial and anti -inflammatory effects, and was advised to decrease the amount of roughage in his diet.
01:08
The question here says, what are some of the possible causes of inflammatory bowel disease? so in this case, the exact cause of inflammatory bowel disease is not fully understood, and it is believed to be a result of a combination of genetic, environmental, and immune system factors.
01:25
So here you have some causes that are going to contribute to inflammatory bowel disease.
01:31
For example, the first one is going to be genetic factors.
01:38
There is some evidence of a genetic predisposition to inflammatory bowel disease, as it tends to run in families.
01:45
Then you have also immune system dysfunction.
01:57
Inflammatory bowel disease is considered an autoimmune disorder, where the immune system mistakenly attacks the body's own healthy tissues in the digestive tracts.
02:07
You have also environmental factors, specifically environmental triggers, such as certain infections, diet, smoking, and stress, may contribute also to the development of or preservation of inflammatory bowel disease in susceptible individuals.
02:36
And, well, you can also have dysbiosis of gut microbiota.
02:50
Okay, alterations in the composition and balance of the gut microbiota, it means that microorganisms living in intestines have been associated with inflammatory bowel disease, and it is believed that an imbalance in the gut microbiota may trigger an abnormal immune response...