The conversion of pyruvate to acetyl CoA is catalyzed by A massive supramolecular complex. A single enzyme. Three different enzymes in different parts of the cell. Three enzyme molecules bound inside the mitochondrial matrix. An enzyme with three amino acid chains.
Added by John L.
Close
Step 1
This process occurs in the mitochondrial matrix and involves a multi-enzyme complex called the pyruvate dehydrogenase complex. Show more…
Show all steps
Your feedback will help us improve your experience
Suman K and 84 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
3. List the 3 proteins in the complex involved in the conversion of pyruvate to acetyl CoA? 1) 2) 3) 4. List all the cofactors/coenzymes involved in the protein complex in question (3) above. 5. Why is oxaloacetate important as a reaction partner for acetyl CoA feeding into the citric acid cycle?
Suman K.
The conversion of pyruvate to acetyl-CoA and carbon dioxide depends on the coenzyme biotin. It is activated when the pyruvate dehydrogenase complex is phosphorylated by a protein kinase in the presence of ATP. The conversion also involves the participation of lipoic acid and is reversible.
Sukhada S.
The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. E1, E2, and E3 are abbreviations for the enzymes of the complex. Classify the enzyme names, prosthetic groups, and reactions as E1, E2, or E3. E1 E2 E3 pyruvate dehydrogenase dihydrolipoyl transacetylase (dihydrolipoamide acetyltransferase) dihydrolipoyl (dihydrolipoamide) dehydrogenase thiamine pyrophosphate (also called TPP or TDP) lipoamide (or lipoate) FAD formation of hydroxyethyl-TPP transfer of acetyl group to coenzyme A hydroxyethyl group transferred to lipoamide dihydrolipoamide is oxidized to lipoamide
Supreeta N.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD