Question

f) The enantiomers of the drug thalidomide have different pharmacological properties. Provide a chemical mechanism to explain why the R-enantiomer, which acts as sedative, will undergo significant racemisation to give the teratogenic S-enantiomer under physiological conditions. 00 H N N- 0 R-thalidomide

          f)
The enantiomers of the drug thalidomide have different pharmacological properties.
Provide a chemical mechanism to explain why the R-enantiomer, which acts as sedative,
will undergo significant racemisation to give the teratogenic S-enantiomer under
physiological conditions.
00
H
N
N-
0
R-thalidomide

f)
The enantiomers of the drug thalidomide have different pharmacological properties.
Provide a chemical mechanism to explain why the R-enantiomer, which acts as sedative,
will undergo significant racemisation to give the teratogenic S-enantiomer under
physiological conditions.
00
H
N
N-
0
R-thalidomide

Added by Nerea S.

Chemistry: Structure and Properties

Nivaldo Tro 2nd Edition

Instant Answer

Solved by Expert Oluwapelumi Kolawole

Step 1

Enantiomers are molecules that are mirror images of each other and cannot be superimposed onto each other. This property is due to the presence of a chiral center, a carbon atom bonded to four different groups. In the case of thalidomide, the chiral center is Show more…

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The enantiomers of the drug thalidomide have different pharmacological properties Provide a chemical mechanism to explain why the R-enantiomer,which acts as sedative will undergo significant racemisation to give the teratogenic S-enantiomer under physiological conditions. R-thalidomide