The following data is of IREM-1 expression in acute myeloid leukemia (AML) cell lines. IREM-1 Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Receptor number per cell 20000 10000 0 EOL-1 HL-60 Kasumi 1 Kasumi 3 Kasumi 6 KG1 MEG-1 ML2 Molm13 Monomac 6 MV4-11 NB4 OCI-AML5 U937 OCI-AML2 TF-1 Me07 Kasumi 4 b IREM-1 beta-actin EOL-1 HL-60 K562 Kasumi-1 Kasumi-3 Kasumi-6 KG-1 MEG-1 ML-2 MOLM-13 Monomac-6 MV4-11 NB-4 CI-AML-5 U937 Please answer the following questions: 11. True or False: Western Blots detect protein expression. 12. True or False: The EOL-1 AML cell line has high IREM-1 expression. 13. True or False: The CI-AML-5 AML cell line has high IREM-1 expression. 14. True or False: The MEG-1 AML cell line has moderate IREM-1 expression. 15. True or False: The HL-60 AML cell line has low IREM-1 expression. 16. True or False: The K562 AML cell line has no relative IREM-1 expression. 17. True or False: The U937 AML cell line has greatest IREM-1 expression. 18. True or False: The ML-2 AML cell line has great IREM-1 protein expression. 19. True or False: The beta-actin expression is used a control against IREM-1 expression. 20. True or False: No IREM-1 protein expression is found in NB-4 cells.
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