The inappropriate overexpression of the growth factor receptor HER2 by amplification in 15% of breast cancer is a prime example of which hallmark? Group of answer choices Sustaining proliferative signaling Evading growth suppressors Resisting cell death Enabling replicative immortality Inducing angiogenesis Activating invasion and metastasis Deregulating cellular energetics and metabolism Avoiding immune destruction Genome instability with mutation Tumorāpromoting inflammation
Added by Jasmine J.
Step 1
HER2 is a growth factor receptor that, when overexpressed due to gene amplification, leads to increased signaling for cell growth and division. Show moreā¦
Show all steps
Your feedback will help us improve your experience
Adi S and 58 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
B2: The mutated Her2 activates the PI3 Kinase-Akt signaling pathway. This signaling contributes to the development of breast cancer via ____. Group of answer choices Sustained Angiogenesis Resistance to apoptosis Self-sufficiency in growth signals Tissue invasion and metastasis
Adi S.
1. Gain of function mutations in cancer impact which class of genes? Tumor suppressor genes Both oncogenes and tumor suppressor genes Oncogenes Neither oncogenes or tumor suppressor genes 2. A declining death rate in the United States means that there are fewer individuals dying each year than the previous year. True or False. 3. The characteristic of cancer cells that enables the other hallmarks of cancer is ___________. Sustaining proliferative signaling Enabling replicative immortality Genomic instability Angiogenesis
Which of the following is NOT a hallmark of cancer? Resistance to signals that slow cell division or promote death. Ability to stimulate growth of blood vessels to provide nutrients to the rapidly growing tumor. Metastasis, which allows invasion of local tissues. Ability of cells to inhibit cell division when conditions are not optimal. Cell division in the absence of growth signals.
Madhur L.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
Watch the video solution with this free unlock.
EMAIL
PASSWORD