The most important function of the JGA is to release this hormone in response to a drop in renal BP or blood flow angiotensin I renin angiotensin converting enzyme (ACE) aldosterone angiotensin II
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The JGA is responsible for regulating blood pressure and the filtration rate of the glomerulus. Show more…
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A decrease in blood pressure causes the juxtaglomerular cells to release the enzyme renin. The enzyme released by the juxtaglomerular cells converts the compound to angiotensin I. This product is then converted to angiotensin II by angiotensin-converting enzyme. The final product of this metabolic pathway can cause vasoconstriction of efferent arterioles. This effect helps to minimize the decrease in GFR due to low blood pressure. The final product also stimulates the release of the hormone aldosterone, which stimulates tubular reabsorption of sodium.
Madhur L.
Complete each statement by using the appropriate word or phrase from the list. A decrease in blood pressure is sensed by the macula densa, resulting in stimulation of JG cells. The JG cells respond by secreting renin into the plasma, which eventually encounters angiotensinogen from the liver. Angiotensinogen is converted to angiotensin I as a result of the action of the enzyme renin. Now 10 amino acids long, angiotensin I continues to circulate until being acted upon by ACE. ACE from the lungs finalizes the conversion of angiotensin I to angiotensin II. Now in an active form, angiotensin II binds to target cells in three distinct areas of the body. The resulting actions of angiotensin II cause the release of ADH from the hypothalamus, release of aldosterone from the renal cortex, and widespread vasoconstriction.
Adi S.
Sri K.
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