The normal values for forms of hemoglobin found in an infant under the age of 1 year are 90-95% hemoglobin F; up to 5% hemoglobin A1 and Over the age of 1 are 90-95% hemoglobin A1; up to 2% Hgb F; up to 3% Hgb A2. 1. Are they are the same, why? 2. If they are different, why? 3. List four causes of a hyperplastic marrow. 4. What would you expect to see on microscopic examination of a stained blood smear if the patient has had a splenectomy and why?
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Hemoglobin values in infants and adults are different because of the different oxygen-carrying capacities required at different stages of life. Hemoglobin F (fetal hemoglobin) has a higher affinity for oxygen than hemoglobin A1, which is beneficial for the fetus Show more…
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Fetal hemoglobin (Hb-F) is comprised of two alpha and two gamma chains (which are 72% identical to beta chains, overall). One important difference is the presence of a serine residue at position 143 in place of a histidine residue. Position 143 is associated with the 2,3-BPG binding site. Given this information, does 2,3-BPG bind more or less effectively to Hb-F (as compared to Hb-A)? Briefly explain. How is this difference in amino acid sequence between fetal and maternal hemoglobin important for successful oxygenation of the fetus?
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