00:01
So first, we are going to define what each of these different types of approaches would entail.
00:08
So first we're going to look at genome -wide association studies.
00:13
So what a genome -wide association study is, is it's an approach that involves rapidly scanning different markers across complete sets of dna or complete genomes of many different organisms.
00:28
And it's done to find genetic variations associated with a particular disease.
00:37
And then once these genetic associations are identified, researchers can use this information to detect this disease in other organisms.
00:50
Positional cloning, or b, positional cloning is used to locate the position of a disease associated gene on a chromosome.
01:03
So this can be used to help find out about the disease, even when nothing is known about the role of the genes encoded protein in the disease.
01:17
So the position of the genome that you're trying to really zero in on by a series of steps is what we're doing here.
01:30
So we're going from a larger view to a narrower view to kind of finally determine the specific single base pair that's had a mutation.
01:46
In a map -based approach, this involves dividing the chromosome into smaller fragments that can be propagated and characterized and then ordering them or mapping them.
02:03
To correspond to their respective locations on the chromosome.
02:08
So after the mapping is complete, then you can determine the base sequence of each of the ordered dna fragments.
02:20
Forward genetics identifies the genetic basis of a disease...