The three Complement pathways utilize different means of achieving the same three goals: opsonization, cytolysis and inflammation. It is how the pathways are activated that differs between each of them. Which of the following statements is NOT true? The Classical Complement Cascade was discovered first and is usually triggered by antibodies that are bound to an invading agent.The Alternative Pathway to complement activation was discovered secondarily and requires alternative proteins to activate the cascade.The Lectin Pathway is not activated by antibodies but by a blood protein (mannose-binding lectin) that combines with certain sugars on the microbe’s surface.The entire Complement cascade is triggered by the C3 protein, named for the order in which it was discovered, not its position in the cascade.
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Although the complement cascade can be initiated by antibodies bound to the surface of a pathogen, complement activation is generally considered to be an innate immune response. This is because: Two of the three pathways for complement activation are initiated by constitutively produced recognition molecules that directly interact with microbial surfaces. When the complement cascade leads to the formation of a membrane-attack complex, the pathogen is killed. Several of the soluble products generated by complement activation promote the inflammatory response. Complement proteins bound to the pathogen promote uptake and destruction by phagocytic cells. The C3 convertase is only produced when complement activation is initiated by antibody binding to a pathogen.
Sri K.
QUESTION 13 Which of the following statements about the complement pathways is FALSE? They are all part of the innate immune response. They are all activated at the same time starting from 0 - 4 hours. They all form C3b which binds to the pathogen surface. They all initiate the formation of the membrane attack complex. QUESTION 14 Which of the following choices shows the complement pathways in their correct order of activation? classical pathway ; alternative pathway ; mannose-binding lectin pathway classical pathway ; mannose-binding lectin pathway ; alternative pathway alternative pathway ; mannose-binding lectin pathway ; classical pathway mannose-binding lectin pathway ; classical pathway ; alternative pathway ; QUESTION 15 If an individual was deficient in the CD59 protein, what could happen during a bacterial infection? pathogens would not be tagged with C3b no C3 convertase would form at the host cell surface membrane attack complexes could form on host cell surfaces macrophages would be unable to phagocytose the invading pathogens
All of the following are true of the classical pathway of complement activation except one. Select the one answer that does NOT describe the classical pathway of complement activation. Classical activation will result in enhanced inflammation, opsonization as well as formation of MAC proteins. It requires that circulating antibodies are bound to antigens. It activates T helper cells by presenting antigen to them. It is an example of overlap between innate and adaptive immune function.
Madhur L.
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