Question

These terms should be a key part of your answer: Barr bodies, Xist gene, Xist RNA, methylation, silencing. 3. The Klinefelter’s abnormalities (XXXY, XXXXY, XXXYY, XXYY) or Poly X Syndrome (XXXX), show some mental impairment, but not to the degree of Trisomy 21. The following two hypotheses have been proposed. What are the implications of each hypothesis for the syndromes above? a. X-inactivation occurs ~16 days after fertilization. b. A few genes on the pseudo-autosomal regions of the ‘X’ chromosomes escape inactivation. 4. Why are Trisomy 21 children (47, 21) mentally impaired due to the extra autosomal genes, but the following trisomies or monosomies are typically of normal intelligence? a. Poly X syndrome (47, XXX) b. Klinefelter’s Syndrome (47, XXY) c. Jacob’s Syndrome (47, XYY) d. Turner’s Syndrome (XO)

          These terms should be a key part of your answer: Barr bodies, Xist gene, Xist RNA,
methylation, silencing.

3. The Klinefelter’s abnormalities (XXXY, XXXXY, XXXYY, XXYY) or Poly X
Syndrome (XXXX), show some mental impairment, but not to the degree of Trisomy
21. The following two hypotheses have been proposed. What are the implications of
each hypothesis for the syndromes above?
a. X-inactivation occurs ~16 days after fertilization.
b. A few genes on the pseudo-autosomal regions of the ‘X’ chromosomes escape
inactivation.

4. Why are Trisomy 21 children (47, 21) mentally impaired due to the extra autosomal
genes, but the following trisomies or monosomies are typically of normal intelligence?
a. Poly X syndrome (47, XXX)
b. Klinefelter’s Syndrome (47, XXY)
c. Jacob’s Syndrome (47, XYY)
d. Turner’s Syndrome (XO)

These terms should be a key part of your answer: Barr bodies, Xist gene, Xist RNA,
methylation, silencing.

3. The Klinefelter’s abnormalities (XXXY, XXXXY, XXXYY, XXYY) or Poly X
Syndrome (XXXX), show some mental impairment, but not to the degree of Trisomy
21. The following two hypotheses have been proposed. What are the implications of
each hypothesis for the syndromes above?
a. X-inactivation occurs 16 days after fertilization.
b. A few genes on the pseudo-autosomal regions of the ‘X’ chromosomes escape
inactivation.

4. Why are Trisomy 21 children (47, 21) mentally impaired due to the extra autosomal
genes, but the following trisomies or monosomies are typically of normal intelligence?
a. Poly X syndrome (47, XXX)
b. Klinefelter’s Syndrome (47, XXY)
c. Jacob’s Syndrome (47, XYY)
d. Turner’s Syndrome (XO)

Added by Misty S.

Question

Please give Ace some feedback