Thiazide diuretics exert their diuretic effect via blockage of the sodium-chloride (Na/CI) channel in the apical side of distal convoluted tubule (DCT) epithelial cells. When the Na/Cl channel is blocked, the action of the sodium-potassium (Na/K) pump on the basolateral side of the DCT cells is also decreased. Based on this which of the following are plausible effects of thiazide diuretics? Less K+ is secreted from plasma. Can lead to increase aldosterone release due to decrease in Na+ in plasma The resulting high aldosterone secretion can lead to hypokalemia Less Na+ is reabsorbed into plasma.
Added by Juana S.
Close
Step 1
This blockage also decreases the action of the Na/K pump on the basolateral side of the DCT cells. Show more…
Show all steps
Your feedback will help us improve your experience
Sri K and 73 other Biology educators are ready to help you.
Ask a new question
Labs
Want to see this concept in action?
Explore this concept interactively to see how it behaves as you change inputs.
Key Concepts
Recommended Videos
One type of diuretic given to people with high blood pressure, renal disease, and congestive heart failure are thiazide-type diuretics. These drugs inhibit sodium ion reabsorption by inhibiting the transport in the ascending limb of the loop of Henle. What does it mean to inhibit the transport of sodium ions in the loop of Henle? B) Explain how this inhibition of sodium ions in the loop of Henle could help increase urine production. Explain why people who get inner ear infections often experience dizziness. Identify the action or effect of the following hormones: Hormone: Calcitonin Action or Effect: Hormone: Luteinizing hormone (LH) Action or Effect: Hormone: Glucagon Action or Effect: Hormone: Progesterone Action or Effect:
Sri K.
Thiazide is a drug that decreases the reabsorption of Na in the early portion of the distal tubule. Predict the effects of thiazide (increase/decrease/no change) on each of the following parameters. A. Na+ B. K+ C. Cl- D. HCO3- E. urine flow rate Explain the mechanism by which thiazide produces these effects.
Madhur L.
Adi S.
Recommended Textbooks
Biology for AP Courses
Objective Biology for NEET
Introduction to General, Organic and Biochemistry
Transcript
18,000,000+
Students on Numerade
Trusted by students at 8,000+ universities
Watch the video solution with this free unlock.
EMAIL
PASSWORD